NCT01644825已完成2 期
MITO-11: A Randomized Multicentre Phase II Trial With Pazopanib and Weekly Paclitaxel vs Weekly Paclitaxel in Platinum Resistant or Refractory Ovarian Cancer
National Cancer Institute, Naples20 个研究点 分布在 1 个国家目标入组 72 人开始时间: 2010年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 72
- 试验地点
- 20
- 主要终点
- progression free survival
研究概览
简要总结
The purpose of this study is to evaluate the safety and activity of adding pazopanib to weekly chemotherapy with paclitaxel for patients with ovarian cancer that is resistant or refractory to treatment with platinum based therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Cytologic / histologic diagnosis of stage IC-IV ovarian cancer
- •Disease progressed during first line chemotherapy or disease relapsed within 6 months after the last platinum treatment
- •Disease evaluable by RECIST or Ca 125 GCIG criteria
- •No residual peripheral neurotoxicity from previous chemotherapy treatment
- •Aged at least 18 and not greater than 75 years.
- •Life expectancy of at least 3 months
- •Able to swallow and retain oral medication
- •Written informed consent prior to performance of study specific procedures or assessments
- •Ability and willingness to comply with treatment and follow up assessments and procedures
排除标准
- •· • Previous or concomitant malignant neoplasia (not including basocellular or spinocellular skin carcinoma or in-situ carcinoma of the uterine cervix, provided they are being adequately treated)
- •Previous treatment with weekly paclitaxel
- •More than 2 previous chemotherapy treatments
- •Serious heart disease, including heart failure, atrioventricular block of any degree, serious arrhythmia or history of any one or more of the following cardiovascular conditions within the past 6 months: cardiac angioplasty or stenting, myocardial infarction, unstable angina, symptomatic peripheral vascular disease, coronary artery by-pass graft surgery, class II, III or IV congestive heart failure as defined by the New York Heart Association (NYHA)
- •Hemoglobin < 9 g/dL, neutrophils < 1500/mm3, platelets < 100000/mm3
- •Impairment of renal function (patients should have 2 functioning kidneys): creatinine 1.5 times the upper normal limit - UNL; calculated creatinine clearance < 50 mL/min; urine protein to creatinine ratio > or = 1: then, a 24-hour urine protein must be assessed and subject must have a 24-hour urine protein value <1gr to be eligible
- •Impairment of liver function (SGOT or SGPT > or = 2.5 UNL, alkaline phosphatase > 2.5 ULN, total bilirubin > 1.5 times the UNL)
- •Prothrombin time (PT) or international normalized ratio (INR) or activated partial thromboplastin time (PTT) > 1.2 times the UNL
- •Pregnancy, breast feeding, or inadequate contraception
- •Unable to discontinue prohibited medications (see protocol section 6.7)
- •Clinically significant gastrointestinal abnormalities which might interfere with oral dosing, including but not limited to malabsorption syndrome, major resection of the stomach or small bowel that could affect drug absorption, active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis, other gastrointestinal conditions with increased risk of perforation, history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days prior to beginning study treatment, signs or symptoms of GI obstruction
- •Any unstable or serious concurrent condition
- •Prolongation of corrected QT interval (QTc) >480 ms
- •History of cerebrovascular accident, pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months
- •Macroscopic hematuria
- •Major surgery or trauma within 30 days
- •Hypertension uncontrolled with adequate therapy (systolic blood pressure (BP) of > or = 140mmHg, or diastolic BP of > or = 90mmHg)
- •Any ongoing toxicity from prior anti-cancer therapy that is >Grade 1 and/or that is progressing in severity
- •Present or suspected haemorrhagic syndromes
- •Patients' inability to access the centre due to area of residence
研究组 & 干预措施
paclitaxel
Active Comparator
干预措施: paclitaxel (Drug)
paclitaxel and pazopanib
Experimental
干预措施: paclitaxel (Drug)
paclitaxel and pazopanib
Experimental
干预措施: pazopanib (Drug)
结局指标
主要结局
progression free survival
时间窗: 6 months from randomization
次要结局
- number of patients with objective response(at 2 months and 4 months after randomization)
- worst grade toxicity per patient(at end of each 28 day cycle of therapy)
- overall survival(one year from randomization)
研究者
研究点 (20)
Loading locations...
相似试验
已完成
2 期
Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)GISTNCT01323400Centre Leon Berard81
Unknown
1 期
Pazopanib and Weekly Topotecan in Patients Recurrent Ovarian Cancer (TOPAZ)Ovarian CancerNCT01600573JSehouli68
终止
2 期
Monotherapy Pazopanib in Subjects With Advanced Non-Small Cell Lung CancerLung Cancer, Non-Small CellNCT00549328GlaxoSmithKline14
暂停
2 期
Treatment of Malignant Peritoneal Mesothelioma (MESOTIP)Peritoneal MesotheliomaPeritoneal CarcinomatosisNCT03875144Institut du Cancer de Montpellier - Val d'Aurelle66
已完成
2 期
Pazopanib Plus Lapatinib Compared To Lapatinib Alone In Subjects With Advanced Or Metastatic Breast CancerNeoplasms, BreastNCT00347919GlaxoSmithKline189