A Randomized Controlled Trial of Vitamin D3 Supplementation for the Prevention of Viral Upper Respiratory Tract Infections
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 167
- 主要终点
- To see whether vitamin D3 supplementation during the winter prevents viral URI.
研究概览
简要总结
Background: Vitamin D has been shown to be an important immune system regulator. Vitamin D insufficiency during the winter may cause increased susceptibility to infections, particularly viral upper respiratory tract infections (URIs).
Objective: To determine whether vitamin D supplementation during the winter season prevents or decreases URI symptoms in adults.
Methods: A randomized, double-blind, placebo-controlled trial was conducted in 162 adults. Participants were randomized to receive vitamin D3 50 mcg (2000 IU) daily or matching placebo for 12 weeks from December 2006 to March 2007. A biweekly questionnaire was used to record the incidence and severity of URI symptoms
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ambulatory adult age 18-80 and stable medical condition with no change in medications for 6 months prior to study entry.
排除标准
- •morbid obesity (body mass index > 35 kg/m2)
- •current tobacco use
- •history of hypercalcemia, nephrolithiasis or sarcoidosis
- •pregnancy
- •recent hospitalization
- •current liver or kidney disorders, malignancy and malabsorption
- •use of immunosuppressants or medications that interfere with vitamin D metabolism such as phenytoin and carbamazepine.
结局指标
主要结局
To see whether vitamin D3 supplementation during the winter prevents viral URI.
时间窗: 3 months
次要结局
未报告次要终点