Kinetics of Plasma and Serum Levels of Brain-Derived Neurotrophic Factor (BDNF) in Patients With Ischemic Stroke: Effect of Intravenous Fibrinolysis With Rt-PA
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Measurement of plasma levels of BDNF
研究概览
简要总结
The aim of this study is to show for the first time that treatment with intravenous fibrinolysis using rt-PA in patients with recent ischemic stroke is accompanied by increases in circulating levels of BDNF, which may reflect an increase in BDNF synthesis in the brain.
The analysis of the recovery of functional and cognitive abilities as well as mood at 3 months will allow us to study the impact of BDNF on these parameters. Thus, depending on the results obtained, circulating BDNF could serve as an early marker of these.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients (or their person of trust in cases of inability) who have been informed about the research and given their consent to take part
- •Patients aged 18 years or older
- •Patients who have suffered a de novo recent ischemic stroke < 12 hours
- •Patients who had cerebral imaging (CT-Scan or MRI)
- •Ischemic stroke severity, measured by the National Institute of Health Stroke Score (NIHSS), between 4 and 20
排除标准
- •Patients without national health insurance cover
- •Patients with a clinical history of stroke
- •Patients with cerebral or sub-arachnoid haemorrhage
- •Patients with a transient ischemic attack
- •Time of symptom onset unknown
- •Patients with severe aphasia at the time of the ischemic stroke defined by a sub-score for item 9 (best language) of the NIHSS ≥ 2
- •Patients with dementia prior to the ischemic stroke
- •Patients with a significant loss of autonomy prior to the ischemic stroke, defined by a Rankin score ≥ 4
- •Patients with aphasia before the ischemic stroke
- •Patients with a contra-indication for cerebral MRI
- •Pregnant or breast-feeding women
- •Adults under guardianship
- •Subjects in custody
- •Patients who do not speak French
研究组 & 干预措施
Patients with fibrinolysis
干预措施: Blood samples (Biological)
Patients with fibrinolysis
干预措施: Cerebral MRI (Other)
Patients without fibrinolysis
干预措施: Blood samples (Biological)
Patients without fibrinolysis
干预措施: Cerebral MRI (Other)
结局指标
主要结局
Measurement of plasma levels of BDNF
时间窗: Change from baseline at Day1, Day 7 and Month 3
Measurement of serum levels of BDNF
时间窗: Change from baseline at Day1, Day 7 and Month 3
次要结局
未报告次要终点