Factors Associated With Mortality in the Intensive Care Unit From the Orinoco Region. An Observational Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
ICU mortality indicates the severity of disease, healthcare quality, and the efficacy of interventions. The severity scores are tools to predict the risk of mortality in the ICU, and the APACHE II score is frequently used for this purpose. However, studies validating the score in Colombia are limited. There is uncertainty about the precision and discrimination capacity of the APACHE II score in a population that varies from the original, with varying diseases, and in a different timeline. The investigators determined to evaluate: 1. Evaluate the rate of mortality in the ICU by type of disease and type of admission. 2. The factors associated with mortality. 3. Validate the performance of the APACHE II score as a predictor of mortality.
详细描述
Introduction Mortality serves as an indicator of healthcare quality in the intensive care unit. The APACHE II score is a practical tool for predicting mortality, though its application varies. Studies validating the APACHE II score in Colombia are limited. This study aimed to evaluate the performance of the Acute Physiology and Chronic Health Evaluation (APACHE) II score as a predictor of mortality in the intensive care unit of a hospital in Villavicencio, Colombia.
Methodology Design: In this single-center, retrospective cohort, consecutive cases were observed from admission to discharge from the ICU. The demographic characteristics, diagnosis type, admission origin, and APACHE II score were systematically calculated on a database, and the cases were divided into two populations for comparison based on the outcome.
Setting: The study was performed in the ICU of Hospital Departamental de Villavicencio, a reference institution for the Orinoco region. It has 350 beds, four adult polyvalent critical care units with 40 beds, and the only oncology unit in the zone.
Patients: Critically ill patients admitted from January 2022 to June 2025 were included.
Sample: The study included all patients in the discharge database and used no sampling method.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adult patients older than 18 admitted to the intensive care unit during the study period.
排除标准
- •Patients admitted for intermediate care (low therapeutic intervention with a TISS [Therapeutic Intervention Scoring System] - 28 score below 20 points). Patients derived to other institutions.
研究组 & 干预措施
ICU mortality
Patients who died in the intensive care unit within the first 28 days of admission.
干预措施: Exposure factors (Other)
ICU survivors
Patients discharged from the intensive care unit alive within the first 24 days.
干预措施: Exposure factors (Other)
结局指标
主要结局
Mortality
时间窗: Within 28 days
Dead discharges
次要结局
未报告次要终点
研究者
Norton Perez-Gutierrez, MD
ICU director
Hospital Departamental de Villavicencio