Assessment of Silent Brain Injury in Chronic Total Occlusion Patients With Percutaneous Coronary Intervention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Baseline Neuron-specific Enolase (NSE) measurement
研究概览
简要总结
This study examines the formation mechanism and patient-related factors of silent cerebral infarcts, whose importance has become increasingly recognized in patients undergoing percutaneous coronary intervention.
详细描述
This study was produced from the assistant's thesis and was previously accepted as a poster at EuroPCR 2020. We recently completed the full-length article.
This thesis study was supported by Ondokuzmayis University.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CTO and Non-CTO patients undergoing percutaneous coronary intervention
排除标准
- •baseline NSE elevation
- •acute coronary syndromes or cardiac surgery within 4 weeks
- •patients with a cerebrovascular accident
- •intracranial hemorrhage
- •and head trauma
- •central nervous system tumor
- •degenerative central nervous system disorders and neuroendocrine tumors
结局指标
主要结局
Baseline Neuron-specific Enolase (NSE) measurement
时间窗: NSE blood levels were measured 1-2 hours before the procedure.
Baseline NSE measurement to exclude non-PCI dependent brain injury. Elevation of \>20 ng/ml was considered as silent brain injury. Patients with basal nse elevation were considered as SBI and excluded from the study.
Silent Brain Injury diagnosis
时间窗: 12-18 hours after percutaneous coronary intervention
NSE blood levels were measured 12-18 hours after the procedure. Elevation of \>20 ng/ml was considered as SBI.
次要结局
未报告次要终点
研究者
Muhammet Uyanik
Principal Investigator
Ondokuz Mayıs University