KCT0002072招募中未知
Cost effectiveness of diagnostic methods for dementia patient in community and hospital (Sub-project1: Evaluation of diagnostic value and development of application standards of brain amyloid imaging in patients with Alzheimer’s disease)
Koera University Guro Hospital0 个研究点目标入组 900 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 900
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational Study
入排标准
- 年龄范围
- 60(Year) 至 o Limit（—）
- 性别
- All
入选标准
- •The diagnosis of dementia due to Alzheimer’s disease from the National Institute on Aging-Alzheimer’s Association
- •¦ Dementia is diagnosed when there are cognitive or behavioral (neuropsychiatric) symptoms that:
- •1. Interfere with the ability to function at work or at usual activities; and
- •2. Represent a decline from previous levels of functioning and performing; and
- •3. Are not explained by delirium or major psychiatric disorder;
- •4. Cognitive impairment is detected and diagnosed through a combination of (1) history-taking from the patient and a knowledgeable informant and (2) an objective cognitive assessment, either a bedside” mental status examination or neuropsychological testing. Neuropsychological testing should be performed when the routine history and bedside mental status examination cannot provide a confident diagnosis.
- •5. The cognitive or behavioral impairment involves a minimum of two of the following domains:
- •a. Impaired ability to acquire and remember new information
- •b. Impaired reasoning and handling of complex tasks, poor judgment
- •c. Impaired visuospatial abilities
- •d. Impaired language functions
- •e. Changes in personality, behavior, or comportment
- •¦ Probable Alzheimer's disease: Core clinical criteria
- •Probable Alzheimer's disease is diagnosed when the patient
- •1.Meets criteria for dementia described earlier in the text, and in addition, has the following characteristics:
- •A. Insidious onset. Symptoms have a gradual onset over months to years, not sudden over hours or days;
- •B. Clear-cut history of worsening of cognition by report or observation; and
- •C. The initial and most prominent cognitive deficits are evident on history and examination in one of the following categories.
- •a. Amnestic presentation
- •b. Nonamnestic presentations:
- •? Language presentation
- •? Visuospatial presentation
- •? Executive dysfunction
- •D. The diagnosis of probable Alzheimer's disease should not be applied when there is evidence of (a) substantial concomitant cerebrovascular disease, defined by a history of a stroke temporally related to the onset or worsening of cognitive impairment; or the presence of multiple or extensive infarcts or severe white matter hyperintensity burden; or (b) core features of Dementia with Lewy bodies other than dementia itself; or (c) prominent features of behavioral variant frontotemporal dementia; or (d) prominent features of semantic variant primary progressive aphasia or nonfluent/agrammatic variant primary progressive aphasia; or (e) evidence for another concurrent, active neurological disease, or a non-neurological medical comorbidity or use of medication that could have a substantial effect on cognition.
- •¦ Possible Alzheimer's disease: Core clinical criteria
- •A diagnosis of possible Alzheimer's disease should be made in either of the circumstances mentioned in the following paragraphs.
- •1. Atypical course
- •Atypical course meets the core clinical criteria in terms of the nature of the cognitive deficits for Alzheimer's disease, but either has a sudden onset of cognitive impairment or demonstrates insufficient historical detail or objective cognitive documentation of progressive decline
- •2. Etiologically mixed presentation
- •Etiologically mixed presentation meets all core clinical criteria for Alzheimer's disease but has evidence of (a) concomitant cerebrovascular disease, defined by a history of stroke temporally related to the onset or worsening of cognitive impairment; or the presence of multiple or
排除标准
- •1. has altered consciousness such as delirium or confusion
- •2. has infectious or inflammatory brain diseases (viral or fungal infection, syphilis, and etc.)
- •3. has evidence of serious cerebrovascular pathology within 3 months
- •4. currently has a major psychiatric illnesses such as a major depressive diorder or bipolar disorder
- •5. has depressive symptoms that may affect cognitive function according to Geriatric Depression Scale
- •6. has medical illness that could cause cognitive decline
- •7. in use of medication that could affect cognitive dysfunction
研究者
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