The Effect of Combined Exercise Training on Cognitive Functions in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- cognitive function
研究概览
简要总结
It is stated that the affected cognitive functions in Multiple Sclerosis are learning, memory, attention, speed of information processing, visuospatial skills, and executive functions. The speed of information processing, visual learning and memory are the most frequently affected components in MS. For this reason, approaches to increase cognitive functions by activating neuroprotective mechanisms such as exercise in patients with MS are needed.
The purpose of this study is to examine the effect of combined exercise training on cognitive functions in patients with MS.
详细描述
The study was designed as a randomized, controlled, single-blind trial. This study will include patients with MS who 0-5.5 according to the Extended Disability Status Scale (EDSS) and between 18-65 years. The patient will be randomized into a combined training group and a control group. The patients in the control group will not apply an exercise training. The combined exercise training group will be given combined exercise training, consisting of Pilates and aerobic exercise, three times during 8 weeks. Both groups will be reevaluated 8 weeks after the initial assessment.
Statistical analyses will be performed using the SPSS software version 15 (SPSS Inc. Chicago, IL, USA). The pre-training and post-training measurements of groups will be compared with the Wilcoxon Test. The significance level was set at p< 0.05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
To ensure blinding, the assessor physiotherapist will not be aware of the arm to which the subjects belong
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ambulatory
- •Stable phase of the disease without relapses in the last 3 month
- •EDSS between 2-5,5.
排除标准
- •Orthopedic, vision, hearing, or perception problems
- •Any cardiovascular or pulmonary disease in which exercise is contraindicated
研究组 & 干预措施
combined exercise training group
The combined exercise training group will be given combined exercise training, consisting of Pilates and aerobic exercise, three times during 8 weeks.
干预措施: combined exercise training (Other)
Control group
The patients in the control group will not apply an exercise training.
结局指标
主要结局
cognitive function
时间窗: Thirty minutes]
The Brief Repeatable Battery of Neuropsychological Tests
次要结局
- Multiple Sclerosis Quality of Life-54(ten minutes)
- functional exercise capacity(ten minutes)
- Fatigue(five minutes)
研究者
Cagla Ozkul
research assistant
Gazi University