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临床试验/NL-OMON50953
NL-OMON50953撤回不适用

Enhancement of immune response by combining immune checkpoint blockade and radiation in patients with recurrent / refractory malignant lymphoma (re-directing the immune system). - RIMAL1

Radboud Universitair Medisch Centrum0 个研究点目标入组 20 人开始时间: 待定最近更新:
适应症

试验速览

阶段
不适用
状态
撤回
入组人数
20

研究概览

简要总结

暂无简介。

研究设计

研究类型
Interventional

入排标准

年龄范围
18 至 99(—)

入选标准

  • - patients with refractory / recurrent malignant lymphoma eligible for ICB
  • - aged 18 - 75 year
  • - WHO score >=2
  • - adequate organ function
  • neutrophil count
  • serum creatinine
  • - no prior treatment with checkpoint inhibitors
  • - no non-infectious pneumonitis requiring steroids
  • - not pregnant
  • - patients of childbearing/reproductive potential should use 2 birth control
  • - written informed consent

排除标准

  • - Not fit (mentally or physically) to undergo the proposed treatment.
  • - Patients with connective tissue diseases (inflammatory myopathy (polymyositis
  • and ermatomyositis), systemic lupus erythematosus, Sjögren syndrome, systemic
  • sclerosis, antisynthetase syndrome, rheumatoid arthritis, severe psoriasis and
  • mixed CTDs), vasculitis (granulomatosis with polyangiitis (Wegener*s
  • granulomatosis), microscopic polyangiitis, eosinophilic granulomatosis with
  • polyangiitis (Churg-Strauss syndrome), severe Behçet disease, Takayasu
  • arteritis, giant cell arteritis, Buerger disease, Kawasaki disease,
  • polyarteritis nodosa, severe immunoglobulin A (IgA) vasculitis (Henoch-
  • Schönlein purpura), severe cutaneous vasculitis, polymyalgia rheumatica, severe
  • cryoglobulinaemia and undifferentiated systemic vasculitis) and other
  • autoimmune diseases (primary biliary cirrhosis, severe autoimmune hepatitis,
  • multiple sclerosis, severe antiphospholipid syndrome, myasthenia gravis,
  • Guillain-Barré syndrome, inflammatory bowel disease, Miller-Fisher syndrome,
  • Vogt-Koyanagi-Harada syndrome, eosinophilic fasciitis (Shulman syndrome),
  • relapsing polychondritis and severe autoinflammatory diseases) ( Martins et al.
  • - Sensory or motor peripheral neuropathy > grade 2.

研究者

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