Assessment of Influence of Vitamin D on Insulin Secretion and Sensitivity in Obese Teenage Girls (Assessment of Prevalence of Vitamin D Deficiency in Obese Teenage Girls and Influence of Vitamin D on Insulin Secretion and Sensitivity)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The insulin secretory capacity and insulin resistance indices are the outcome of interest in this study.
研究概览
简要总结
The purpose of the study is to assess the relationship between vitamin D status and insulin- glucose dynamics in obese Adolescents. The study is intended to assess the difference in the insulin sensitivity before and after correction of vitamin D deficiency.
详细描述
The vitamin D deficient subjects are identified initially through an existing study. Those identified with vitamin D deficiency are notified and subsequently treated with standard therapy for vitamin D deficiency as part of their clinical care. Patients who self report that they have taken the treatment are enrolled in this study. Patients will be evaluated in this study with measurement of serum 25 OH D level, PTH and oral glucose tolerance test. The study will assess if there is improvement in glucose- insulin sensitivity dynamics once the serum 25OH D level is normalized
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 13 Years 至 18 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female adolescents who are menarchal
- •BMI is 95th centile, for age and sex
- •Patients will be screened for vitamin D deficiency through an existing study.
- •Those found to be vitamin D deficient will be given standard treatment of vitamin D deficiency.
- •In this study, patients who self report that they had taken the treatment for vitamin D will be screened for serum 25 OH D level
排除标准
- •Children with diabetes, other endocrine or acute or chronic medical illnesses, children on oral contraceptive pills, diuretics and anticonvulsant medications
结局指标
主要结局
The insulin secretory capacity and insulin resistance indices are the outcome of interest in this study.
时间窗: December 2009
次要结局
- We will evaluate whether the relationship of obesity and insulin resistance and the defective insulin secretory capacity is modulated by vitamin D status(December 2009)
研究者
Ambika Ashraf, M.D.
Assistant Professor, Pediatrics
University of Alabama at Birmingham