Evaluation of 2%Bromelain Gel With 0.2%Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing in Stage II/III and Grade B Periodontitis -Randomized Control Clinical Trail
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Probing pocket Depth (PPD)
研究概览
简要总结
The current study is a prospective randomised study Evaluation of 2%Bromelain Gel With 0.2%Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing in Stage II/III and Grade B Periodontitis
详细描述
36 sites with periodontal pocket depth measuring 4-6mm were selected. The sites selected were divided into
- Group I (Control)- 12 sites with Probing depth of ≥5mm treated with scaling and root planing alone.
- Group II -12 sites with Probing depth of ≥5mm treated with scaling and root planing followed by placement of bromelain gel.
- Group III -12 sites with Probing depth of ≥5mm treated with scaling and root planing followed by placement of chlorhexidine gel.
periodontal pack was placed and patient was recalled at 1week,4th week and 12th week
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient with have chronic periodontitis in the age group between 30-50 years.
- •Patients having ≥20 teeth.
- •.Patients with radiographic evidence of bone loss in atleast two teeth.
- •Patients who are systematically healthy.
- •Patients with localized pockets with probing depth of ≤ 5mm.
- •Patients who are cooperative and able to attend the hospital for regular follow-up.
排除标准
- •Patients who have received any surgical or nonsurgical therapy during past 6months
- •Pregnant or lactating females.
- •Use of systemic antibiotics in the past 6 months.
- •Patient who are not willing to give a written informed consent
研究组 & 干预措施
GROUP 1-SRP alone
control group is treated with SRP alone
干预措施: SRP (Procedure)
GROUP 2-0.2% BROMELAIN gel
test group is treated with bromelain gel
干预措施: Bromelain gel (Drug)
GROUP 3-0.2% CHLORHEXIDINE gel
test group is treated with chlorhexidine gel
干预措施: chlorhexidine gel (Drug)
结局指标
主要结局
Probing pocket Depth (PPD)
时间窗: 3 months
measured using a UNC-15 probe (university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA
Relative attachment level (RAL)
时间窗: 3 months
(university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA)
次要结局
- Gingival index(3 month)
- Modified Sulcus Bleeding Index(3 months)
- Plaque Index(3 months)