JPRN-UMIN000011372已完成4 期
Brain histamine H1 receptor occupancy of sedating OTC antihistamines: Time-course of receptor occupancy measured by PET in normal volunteers - Histamine H1 receptor occupancy of OTC antihistamines
Department of Pharmacology, Tohoku University Graduate School of Medicine0 个研究点目标入组 8 人开始时间: 2013年8月5日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 8
研究概览
简要总结
Brain histamine H1 receptors were measured using PET and [11C]doxepin at 3 hours and 23 hours consecutively after diphenhydramine (50 mg) or ketotifen (1 mg) intake in healthy, young male subjects. The half-life of diphenhydramine and ketotifen in the brain was estimated to be ~30 hours and 45 hours, respectively.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 30years-old（—）
- 性别
- Male
入选标准
- 未提供
排除标准
- •1. Subjects who take no medication including antihistamines at present. 2. Subjects who do not take any PET scans within the recent 2 years. 3. No serious allergy 4. No convulsion at past 5. No frequent medical addmission 6. No glaucoma and prostatic hypertrophy 7. Subjects who can not take any anticholinergic and antihistaminergic drugs from medical points of view. 8. No brain MRI abnormality 9. Inadequate subjects from the point of medical view of the investigators.
研究者
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