Research on the Mechanism of Dasatinib Down-regulates the Expression of PD-1 in CMV-activated NKG2C+NK Cells and Enhances Killing pH + Leukemia Stem Cells.
试验速览
- 阶段
- 不适用
- 入组人数
- 324
- 试验地点
- 1
- 主要终点
- NK cells and T cell activation subsets in CML-CP patients treated with TKI for 2 years
研究概览
简要总结
Research on the mechanism of dasatinib down-regulates the expression of PD-1 in CMV-activated NKG2C+NK cells and enhances killing pH + leukemia stem cells.
详细描述
Some patients with CML can withdraw from TKIs after treatment, and the mechanism might be related to the effect of memory NK cells on anti-Ph+ leukemic stem cells (LSCs). Dasatinib affects immune through several pathways including the expression of PD1 in immune cells. Our previous work showed increased NKG2C+ NK cells were found in cases with CMV-DNA+ who suffered Ph+ leukemia and received Dasatinib, and these memory NK cells have anti-LSCs activity. We hypothesize that: CMV infection activates NKG2C+ memory NK cells proliferation; Dasatinib down-regulates the expression of PD1 in PD1+NKG2C+ NK cell subsets and then enhances anti-LSCs activity of these cells. In this study, the effect of Dasatinib on CMV-activated NKG2C+ cell subsets and its mechanism will be studies. Besides, the different NKG2C+ cell subsets on LSCs will be compared. This study might be helpful to clarify the mechanism of TKI withdrawal and to offer foundation for CMV and Ph+ ALL treatment strategies
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 years old, gender is not limited
- •CML-CP patients treated with TKIs
- •No pregnancy was planned during the treatment
排除标准
- •1.The researcher judged that it was not suitable to participate in this study
结局指标
主要结局
NK cells and T cell activation subsets in CML-CP patients treated with TKI for 2 years
时间窗: 2 years
NK cells and T cell activation subsets in CML-CP patients treated with TKI for 2 years
次要结局
未报告次要终点
研究者
Dan Xu
professor
Nanfang Hospital, Southern Medical University