NCT05843604招募中不适用
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Cerebral activity modification during N-back task
研究概览
简要总结
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
- •Understand and accept the constraints of the study
- •Be a beneficiary or affiliated to a Health Insurance scheme
排除标准
- •Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- •Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
- •Have a serious intercurrent pathology
- •Being a pregnant woman
- •Being a woman of childbearing age without effective contraception.
- •Being hospitalized under duress or on an outpatient basis in a care program
- •Being under judicial protection (reinforced curatorship, guardianship)
结局指标
主要结局
Cerebral activity modification during N-back task
时间窗: Day 1
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Cerebral activity modification during Stroop task
时间窗: Day 1
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
Cerebral activity modification during switching task (Monsell et Mizon task )
时间窗: Day 1
Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls
次要结局
未报告次要终点
研究者
研究点 (1)
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