Assessment of Retinal Functional Abnormalities in Diabetic Patients Without Retinopathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 1
研究概览
简要总结
The primary purpose was to assess, in diabetic patients without diabetic retinopathy and control subjects, color vision, contrast sensitivity, electroretinography, and flicker-induced vasodilatation using the Dynamic Vessel Analyzer, in order to specify the earliest impaired retinal cells in diabetes, and gain more insight into diabetic retinopathy pathogenesis.
详细描述
Type 1 and type 2 diabetic patients with no diabetic retinopathy and no hypertension were compared with sex and age-matched control subjects. Color vision was tested with the desaturated LANTHONY 15-Hue test. Contrast sensitivity was assessed with the Pelli-Robson contrast sensitivity test. Pattern-electroretinogram, Ganzfeld full-field electroretinogram and multifocal electroretinogram were recorded according to the International Society for Clinical Electrophysiology of Vision (ISCEV). Flicker-induced vasodilatation in retinal arteries and veins was assessed using the Dynamic Vessel Analyzer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For diabetic patients :
- •age between 20 and 55
- •type 1 or type 2 diabetes mellitus
- •diabetes duration of more than 5 years
- •no diabetic retinopathy on fundus examination or fundus photographs
- •For control subjects :
- •sex and age matching with the diabetic patients
- •no diabetes, no familial or personal history of elevated blood sugar
排除标准
- •*For both diabetic patients and control subjects :
- •presence of cataract or history of cataract surgery
- •intraocular pressure of more than 21 mmHg
- •abnormal score on the Ishihara test
- •other ocular disease
- •ametropia more than 3 diopters, anisometropia more than 1 diopter, astigmatism more than 1 diopter
- •systemic hypertension (defined as systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg)
- •treatment with vasoactive drugs
- •tobacco consumption of more than 20 cigarettes a day