NCT00856726已完成不适用
Racial Differences in Phosphorus Metabolism
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Urinary Phosphorus Excretion
研究概览
简要总结
The investigators aim to study potential racial differences in renal phosphorus handling by provocatively testing urinary phosphorus excretion using parathyroid hormone infusions in healthy white volunteers compared to healthy black volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years of age or older
- •Body mass index (BMI) within 20% ideal for their age and gender
排除标准
- •Abnormal urinalysis
- •Pregnancy or breast-feeding
- •Medical conditions impacting phosphorus metabolism-primary hyperparathyroidism; diabetes mellitus; gastrointestinal malabsorption disorders; hyper- or hypothyroidism
- •Medications known to affect phosphorus metabolism- current use of phosphorus supplements, phosphorus binders, calcitriol or calcitriol analogues, regular antacid or laxative use, calcitonin, etidronate, anticonvulsants
- •Hyper- or hypophosphatemia (≥ 4.6 mg/dl or ≤ 2.5 mg/dl respectively), hyper- or hypocalcemia (≥ 10.6 or ≤ 8.5 mg/dl respectively), or severe anemia (Hgb < 8 g/dl for women and < 9 g/dl for men)
研究组 & 干预措施
PTH infusion
Experimental
(1-34) PTH infusion at a rate of 0.055 ug/kg/hour for six hours
干预措施: 1-34 parathyroid infusion (Drug)
结局指标
主要结局
Urinary Phosphorus Excretion
时间窗: six hours
Fractional excretion of phosphorus (the fraction of phosphorus filtered by the kidney which is excreted in the urine)
次要结局
- Fibroblast Growth Factor 23(six hours)
- Serum Phosphorus(six hours)
- Serum Calcium(six hours)
- Parathyroid Hormone(six hours)
- Fractional Excretion of Calcium(six hours)
研究者
Orlando M. Gutierrez, MD, MMSc
Associate Professor
University of Alabama at Birmingham
研究点 (1)
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