Urinary Dickkopf-3 for Prognosis and Monitoring of Glomerular Filtration Rate Decline in Patients With Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 290
- 试验地点
- 1
- 主要终点
- Association between DKK3 and eGFR decline
研究概览
简要总结
The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) decline are needed. Recently, urinary dickkopf-3 (DKK3) has been proposed to predict eGFR decline in patients with CKD, independent of presence of albuminuria. The investigators sought to examine the association between changes in DKK3 levels and eGFR decline in patients with heart failure (HF).
详细描述
The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) decline are needed. Recently, urinary dickkopf-3 (DKK3) has been identified as an stress-induced, renal tubular epithelia-derived, secreted glycoprotein that induces tubulointerstitial fibrosis. Urinary DKK3 has been found to predict eGFR decline in patients with CKD, independent of presence of albuminuria, but its association with eGFR decline in patients with heart failure (HF) is unknown. The investigators sought to examine the association between changes in DKK3 and eGFR decline in patients with HF.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Outpatients ≥18 years of age with diagnosed HF or diabetes or hypertension
排除标准
- •CKD with estimated GFR <20 ml/min/1.73 m2 (2012 CKD-EPI equation)
- •CKD with extracorporeal or peritoneal ultrafiltration due to diuretic-resistant fluid overload
- •active tumor disease
- •inflammatory or autoimmune disease requiring systemic immunosuppressive treatment
- •clinically apparent infections
- •recipients of solid-organ transplants
- •anticipated life expectancy of <12 months
- •likelihood of receiving advanced therapy (mechanical circulatory assist device/cardiac transplant)
- •pregnancy or possibility of pregnancy in the next 12 months
结局指标
主要结局
Association between DKK3 and eGFR decline
时间窗: 24 months
DKK3 and eGFR (CKD-Epidemiology Collaboration equation)
次要结局
- Association of right and left ventricular function with DKK3(24 months)
- Association between proteinuria and DKK3(24 months)
- Persistent or worsening of HF(24 months)
- Association of venous congestion/volume overload with DKK3(24 months)
- Need for renal replacement therapy(24 months)