Utility of Prednisone in the Treatment of Cellulitis
试验速览
- 阶段
- 2 期
- 状态
- 撤回
- 主要终点
- Time to cellulitis resolving
研究概览
简要总结
The prevalence of cellulitis in society is very high, as much as 3% of visits to Emergency Departments are for the treatment of this disease. The treatment of cellulitis varies depending on the severity. Low severity cases are treated with pain control and antibiotics by mouth and high severity are treated with antibiotics intravenously and pain control. The investigator's hypothesis is to see if the addition of steroids, which are known to decrease inflammation, will decrease the length of the disease process. If so, it will decrease the length of stay if IV antibiotics are needed, it will decrease duration of days out of work and decrease the overall pain control required and therefore patient satisfaction.
详细描述
The incidence of cellulitis is about 24.6 cases per 1000 person-years, which is an estimate, since cellulitis is not a reportable disease. In some Emergency Departments up to 3% of visits are for cellulitis. Depending on the severity of the disease, some are treated as outpatients, and others are admitted for IV antibiotics. In some Emergency Departments cases of cellulitis are treated in an observation area for 23 hours with doses of IV antibiotics. My proposed research is to see if the addition of one dose of prednisone the treatment will decrease the inflammatory reaction enough to decrease length of stay and treatment and increase patient satisfaction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-70 years old
- •signs/symptoms of cellulitis
排除标准
- •steroid use in last 2 weeks
- •hx of adrenal insufficiency
- •suspicion for dvt or abcess
- •systemic signs of sepsis
- •ICU admission
研究组 & 干预措施
Prednisone
Use of prednisone to decrease LOS and overall treatment time of cellulitis
干预措施: Prednisone (Drug)
Placebo
干预措施: Placebo Oral Tablet (Drug)
结局指标
主要结局
Time to cellulitis resolving
时间窗: 48 hours after initiation of treatment
次要结局
- Length of stay(after treatment completed)