The effect of vitamin D supplements in diabetic retinopathy in type 2 diabetic patients

Tehran University of Medical Sciences0 个研究点目标入组 100 人开始时间: 待定最近更新: 2019年2月25日

适应症

试验速览

暂无简介。

•Age of at least 35 years
•Patients with type 2 diabetes who are treated with insulin or combined therapy (insulin with antidiabetic pill)
•They have NPDRP without the need for specific ophthalmologic treatment interventions
•HbA1C levels below 8%
•Systolic blood pressure up to 130
•Diastolic blood pressure is up to 80 mmHg
•Normal GFR is proportional to age based on MDRD formula
•The amount of 24-hour urine albumin is less than 300 milligrams.

•The history of any ocular disease (glaucoma, hypertensive retinopathy and cataract), or the history of eye surgery, or previous intra-ocular injections or visual acuity less than 6/10
•History of chronic disease such as sarcoidosis, hyperparathyroidism and seizure, bone cancer or lung and liver cirrhosis and...
•History of bariatric surgery or absorption disorders or any other disease indicating vitamin D intake.
•History of kidney stones
•Pregnancy and lactation
•History of taking phenofibrate, thiazolidinedione, anticonvulsants, or drugs that interfere with the metabolism of vitamin D or produce eye effects, including macular edema.
•The history of severe psychiatric illnesses such as schizophrenia, mood disorders, borderline disorders.
•Regular supplementation of D supplementation in the last three months or during the study (in the control group)
•History of any drug allergy or side effects.
•Participants are reluctant to take drugs or placebo
•Participate in another research project over the past 3 months
•HbA1C levels of 8% and more
•Glucocorticoid intake in the last 3 months
•BMI more than 35
•The amount of 24-hour urine albumin exceeds 300 milligrams
•The GFR is greater than the normal range based on the age-appropriate MDRD formula.

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