NCT03458897已完成不适用
Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Feasibility of obtaining serial scans in patients with sickle cell undergoing marrow transplant
研究概览
简要总结
The primary purpose of this research is to determine if it is feasible to perform serial magnetic resonance imaging (MRI) to evaluate the amount of bone marrow cells (also called cellularity) and iron stores before and after bone marrow transplantation for severe sickle cell disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 5 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 5 years.
- •Diagnosis of SCD ([Hemoglobin SS (Hb-SS), Hemoglobin SC (Hb-SC) or Hemoglobin S-Beta thalassemia (Hb-Sβ) genotype].
- •Patient is a candidate for an allogeneic HCT.
- •Subject or guardians have given informed consent.
- •Exclusion Criteria
- •The need for general anesthesia for MRI.
- •Subjects with implanted magnetic devices (e.g. pacemakers) that may malfunction or move in the strong magnetic field.
- •A subject who is pregnant.
- •Previous HCT.
排除标准
- 未提供
结局指标
主要结局
Feasibility of obtaining serial scans in patients with sickle cell undergoing marrow transplant
时间窗: 110 days post transplant
Feasibility will be measured by the number of subjects who undergo at least 2 of 4 scheduled functional MRI's
次要结局
- MRI and neutrophil engraftment(1 year post transplant)
- MRI and hemoglobin S.(1 year post transplant)
- MRI and chimerism(1 year post transplant)
研究者
Ghada Abusin
Assistant Professor
University of Michigan
研究点 (2)
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