Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis
研究概览
简要总结
Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.
详细描述
This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent
排除标准
- •ones who did not sign the consent form NSAID or steroid users
结局指标
主要结局
Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis
时间窗: up to 3 days
participants will be followed for the duration of hospital stay, till they are discharged in avarage 3 days for postoperative emesis.
次要结局
未报告次要终点
研究者
A.Ozdemir Aktan
professor of surgery
Marmara University