NCT06878638已完成不适用
Impact of Intravenous Nitrate Treatment on Antiplatelet Effects of Clopidogrel in Acute Coronary Syndrome Patients: A Pilot Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Platelet Reactivity Unit level
研究概览
简要总结
This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosed with non-STEMI
- •Patients aged 18 to 75 years
- •positive troponin levels,
- •blood pressure above 120/70 mmHg
排除标准
- •Hemodynamically unstable and requiring urgent intervention,
- •ST elevation on electrocardiography, atrial fibrillation,
- •recurrent angina,
- •use of narcotic analgesics (e.g., morphine), nitrates and glycoprotein IIb/IIIa inhibitors during hospitalization,
- •history of coronary artery bypass graft (CABG) surgery,
- •active infection,
- •uncontrolled hypertension,
- •diabetes, cerebrovascular accident, Use P2Y12 inhibitor, proton pump inhibitor, oral anticoagulant, statin, CYP enzyme-inducing or inhibiting drugs at the time of admission,
- •active systemic disease (e.g., malignancy, thyroid disorders chronic inflammatory diseases, liver dysfunction),
- •left ventricular systolic dysfunction (ejection fraction <50%),
- •glomerular filtration rate <60 mL/min/1.73m2,
- •allergy to ASA or clopidogrel, coagulopathy,
- •platelet counts below 100,000/μl and hematocrit levels below 29%, or exceeding 52%.
结局指标
主要结局
Platelet Reactivity Unit level
时间窗: 48 hours
Platelet Reactivity Unit \<208
次要结局
未报告次要终点
研究者
Hasan ARI
Professor Doctor
Bursa Postgraduate Hospital
研究点 (1)
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