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临床试验/NCT05558527
NCT05558527招募中不适用

Effects of Trauma and Discrimination on the Social Regulation of Threat-related Vigilance and Arousal

University of Nevada, Reno1 个研究点 分布在 1 个国家目标入组 45 人开始时间: 2025年12月18日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
45
试验地点
1
主要终点
Vigilance Related Eye Movements - Number of Eye Fixations

研究概览

简要总结

This study will examine the effects of social support on threat vigilance and arousal using eye tracking. We will also test the moderating effects of trauma and discrimination history.

详细描述

Both interpersonal trauma (IPT) and ethno-racial discrimination amplify risk for hyper-arousal symptoms of posttraumatic stress disorder (PTSD), but the mechanism of this effect is unclear. Prior research suggests that social support plays an important role in regulating emotional responses, a process called social emotion regulation. This study will test whether a history of IPT and/or ethno-racial discrimination influence the social regulation of arousal and vigilance. Social regulation will be tested by contrasting responses under conditions with and without social support.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • In a stable romantic relationship for 6 months or more
  • Normal vision or corrected-to-normal vision
  • Fluent in English

排除标准

  • If vision is corrected-to-normal, needs to use hard contact lenses, bifocal contact lenses, or glasses
  • Experienced a traumatic event within the past 4 weeks

研究组 & 干预措施

Social support from a romantic partner

Experimental

Participants will hold the hand of their romantic partner

干预措施: social support (Behavioral)

Social support from a stranger

Active Comparator

Participants will hold the hand of a stranger

干预措施: social support (Behavioral)

No social support

No Intervention

Participants will hold a stress ball

结局指标

主要结局

Vigilance Related Eye Movements - Number of Eye Fixations

时间窗: Collected from minute 15 to minute 45 of study participation, approximately

Participants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the number of eye fixations per scene. A greater number of fixations during the 10 second presentation of a scene would indicate greater vigilance.

Vigilance Related Eye Movements - Visual Scanning

时间窗: Collected from minute 15 to minute 45 of study participation, approximately

Participants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the proportion of the scene that they look at (fixate on) out of approximately 80 possible sectors. A greater proportion of the scene they fixate on would indicate greater vigilance.

Threat-Related Physiological Arousal - Pupil Dilation

时间窗: Collected from minute 45 to minute 75 of study participation, approximately

Participants will view a series of visual cues (either an 'X' or an 'O') where an 'X' signals a possible (20% probability) aversive auditory stimulus (human scream). We will examine pupil dilation during the task in order to measure arousal in response to uncertain threat. We will calculate average pupil dilation during the wait period after threat cues (X) and after safety cues (O). We will subtract average pupil dilation after safety cues from threat cues to create an index of threat-related arousal. Greater pupil dilation (for threat minus safety cues) would indicate greater threat-related arousal.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Cynthia Lancaster

Associate Professor Psychology/Associate Director, Clinical Training

University of Nevada, Reno

研究点 (1)

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