Use of Pressure Muscle Index to Avoid Over-assistance During Pressure Support Ventilation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Inspiratory effort
研究概览
简要总结
Pressure support ventilation (PSV) is the most commonly used mode in mechanical ventilated patients. Studies have shown that over-assistance was prevalent in patients undergoing PSV. Up to now, no reliable method has been recommended to select an "optimal" inspiratory support level. Pressure muscle index (PMI) was introduced recently to evaluate the degree of spontaneous breathing effort. We hypothesize that PMI might be used as an indicator for over-assistance during PSV. In this randomized crossover study, inspiratory support is set at three levels according to negative, positive and zero PMI. Inspiratory effort, work of breathing, and respiratory mechanics are compared among the three inspiratory pressure support levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mechanical ventilated patients within 48 hours after the transition from a controlled mode to PSV
排除标准
- •History of neuromuscular disease
- •History of diaphragm dysfunction and surgery
- •History of esophageal, gastric or lung surgery
- •Decreased level of consciousness
- •Central respiratory drive dysfunction
- •Considered withholding of life support
结局指标
主要结局
Inspiratory effort
时间窗: 30 minutes
Inspiratory effort is measured as pressure generated by inspiratory muscles using esophageal pressure monitoring.
Work of breathing
时间窗: 30 minutes
Work of breathing is measured by the Campbell diagram and pressure-time-product using esophageal pressure monitoring.
次要结局
- Partial pressure of carbon dioxide in arterial blood (mmHg)(30 minutes)
- Tidal volume (ml)(30 minutes)
- Respiratory rate (breaths/min)(30 minutes)
- Respiratory system compliance (ml/cmH2O)(30 minutes)
- Rapid shallow breathing index(30 minutes)
- The use of accessory respiratory muscle(30 minutes)
- Partial pressure of oxygen in arterial blood (mmHg)(Partial pressure of oxygen in arterial blood)
研究者
Jian-Xin Zhou
Professor
Capital Medical University