Direct Discrimination of Quantum States by the Human Eye With Macular Degeneration
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Perception of the structured light
研究概览
简要总结
Age-related macular degeneration (AMD), is a debilitating eye disease that causes a loss of central vision. The prevalence of AMD increases exponentially with age and causes a significant impact through both medical expenses and the social and economic costs associated with vision loss. AMD is the global leading cause of blindness among people over the age of 60. Detection of this eye disease at early stages coupled with prompt treatment can prevent vision loss; however, modern diagnosis methods are ineffective at diagnosis of AMD before vision loss occurs. While a range of available treatment options has been effective at slowing vision loss due to AMD, no treatment exists which can recover lost vision. The investigators propose to apply tools developed in quantum information science to diagnose AMD before vision has been affected, drastically improving health outcomes for patients with AMD.
详细描述
There has been tremendous progress in generating and detecting structured light which possesses advantageous propagation characteristics such as quantized orbital angular momentum (OAM), non-diffraction, and self-healing. These special beams have found applications in microscopy, encoding and multiplexing of communications, and manipulation of matter. Here the investigators bring the structured light toolbox to vision sciences for the first time and expand the space of possible stimuli.
A healthy macula possesses azimuthally ordered dichroic fibres that act as a radial polarization filter, enabling a typical person to perceive linearly polarized light through the entoptic phenomena known as Haidinger's brushes. Despite significant interest in the application of this phenomenon to the detection of age-related macular degeneration, no device has currently seen widespread adoption in a clinical environment. This is due to the difficulty in observing Haidinger's brush, the imprecise measurements that this test can extract, and the difficulty in instructing patients during these tests.
Leveraging the quantum-inspired toolbox developed in the field of structured light, the investigators can project polarization-coupled OAM states of light directly on a person's retina. This enables the investigators to create arbitrary entoptic patterns in a person's vision based on the structure and chemical composition of their subjective macula, and the investigators have the opportunity to develop a litany of novel diagnostic tests to characterize and quantify the health of the macula.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants who are clinically diagnosed with a vision disease affecting their macula
- •Older adults who are matched for age.
- •Participants who are clinically diagnosed with glaucoma
- •Participants who have normal vision.
- •One aged-matched control with normal vision will be recruited for each of the diagnosed groups (born in the same year).
排除标准
- •Participants with any additional eye diagnosis or condition
研究组 & 干预措施
Participants with Age-Related Macular Degeneration
Conducting the psychophysical task on the perception of OAM-coupled polarized light
干预措施: Structured Light Imaging Microscopy (Device)
结局指标
主要结局
Perception of the structured light
时间窗: Approximately 10 minutes, Screening and Training day (Session 1)
Assessment of the participant's ability to see the entoptic phenomena created using the structured light (SL) - orbital angular momentum (OAM) coupled polarized light. Various SL vortex and radial patterns will be projected using the custom research-based laser optical setup
Radius of the radial retinal polarizer
时间窗: Approximately 30 minutes, on the completion of the study (Session 6)
Calculation of the radius of the central obstruction. From a total of 14 reversal trials, the six last values of the mask size will be used for the calculation of the threshold mask size mean (r mean). The standard deviation will be computed from the variance of these last six trials
次要结局
- Thickness of retina and retinal layers(Approximately 10 minutes, Screening and Training day (Session 1))
- Ocular biometry measurement(Approximately 5 minutes, Screening and Training day (Session 1))
- Macular pigment optical density measurement(Approximately 10 minutes, Screening and Training day (Sessions 1 and 2))
- Fundus photography(Approximately 5 minutes, Screening and Training day (Session 1))
- Contrast sensitivity(Approximately 5 minutes, Screening and Training day (Session 1))