Comparison Of Dexmedetomidine And Ketamine For Control Of Shivering In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia
试验速览
- 阶段
- 3 期
- 入组人数
- 104
- 主要终点
- Change in Shivering grade
研究概览
简要总结
comparison of Dexmedetomidine And Ketamine For Control Of Shivering In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia.
详细描述
In this study the participants aim to Compare Dexmedetomidine And Ketamine For Control Of Shivering In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding efficacy, hamemodynamic stability, outcomes and adverse effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
the drugs will be prepared by anesthesiologist who will not be the part of the study and these drugs will be injected by another anesthesiologist who will be blinded to the drugs and will be participating into the study.
入排标准
- 年龄范围
- 45 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients of age 45-55 years requiring vaginal hysterectomy
- •American Society of Anesthesiology (ASA) of Grade I-II
排除标准
- •Patients unwilling or non-cooperative for spinal anesthesia
- •Patients with uncontrolled hypertension, vascular or coronary disease,
- •patients with increased intraocular or intracranial pressure
- •Patients with known bleeding and psychiatric disorders
- •Patients taking anti platelets drugs.
研究组 & 干预措施
Group Dexmedetomidine
Group Dexmedetomidine receiving I/V bolus of dexmedetomidine 0.1 mg/kg as a 20 ml solution, followed by 0.04mg/kg/hr infusion till surgery completion
干预措施: Dexmedetomidine (Drug)
Group Ketamine
Group Ketamine receiving 0.2 mg/kg iv of ketamine diluted to 20 ml followed by 0.1 mg/kg/hr infusion till surgery completion
干预措施: Ketamine (Drug)
结局指标
主要结局
Change in Shivering grade
时间窗: Shivering grade of patients will be evaluated every 15 minutes interval after giving the drug till 1hour postoperatively
Shivering of patients will be grouped into five grades; Grade 0: lack of shivering, Grade I: slight shivering (inconsiderable yet apparent peripheral vasoconstriction), Grade II: medium level shivering (muscular activity in one muscle group only), Grade III: severe shivering (muscular activity in more than one muscle group without generalized shivering), Grade IV: generalized shivering.
次要结局
未报告次要终点
研究者
Dr. Nida Shahid
Assistant Professor, Anesthesiology
Hamdard University