A Phase I, Intrapatient Dose-Escalation Study of Sorafenib in Advanced or Relapsed Non-Small Cell Lung Cancer (NSCLC)
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Toleration of dose escalation (dose-limiting toxicities)
研究概览
简要总结
The purpose of this study is to determine the number of patients with advanced, relapsed non-small cell lung cancer who can tolerate dose escalation sorafenib from 400 mg twice daily to either 600 mg twice daily or 800 mg twice daily. Safety and tolerability of sorafenib will also be examined.
详细描述
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality in the U.S. Time to progression in advanced disease remains poor and further study of newer agents with novel mechanisms of action is needed to improve duration and quality of life for NSCLC patients.
Sorafenib is an oral-multi-kinase inhibitor with effects on tumor proliferation and tumor angiogenesis. Sorafenib has demonstrated activity in preclinical models of NSCLC both in combination with chemotherapy and as monotherapy. A recent intra-patient dose escalation trial of sorafenib in renal cell carcinoma showed positive response rates and tolerability up to 1200mg in 91% of patients.
This study attempts a similar dose-escalation of sorafenib in NSCLC patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically confirmed, advanced (stage IIIB with pleural effusion, stage IV, or recurrent), kras mutation positive, non-small cell lung cancer (NSCLC)
- •Measurable disease per RECIST criteria
- •Patients must have received one + prior chemotherapy regimens for NSCLC
- •Patients may have treated and clinically stable brain metastases
- •Adequate bone marrow, liver and renal function
- •Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to the start of treatment
- •Women of childbearing potential and men must agree to use adequate contraception (barrier method of birth control) prior to study entry and for the duration of study participation, and for 3 months after last administration of sorafenib
- •Patients must have the ability to understand and willingness to sign a written informed consent
- •International normalized ratio(INR) < 1.5 or prothrombin time/ partial thromboplastin time (PT/PTT) within normal limits
排除标准
- •Prior exposure to a Ras pathway inhibitor
- •Any other anti-tumor therapy within 3 weeks of enrollment
- •Prior bevacizumab within the past 6 weeks
- •An active secondary malignancy except non-melanoma skin cancer
- •Cardiac disease: Congestive heart failure > class II NYHA. Patients must not have unstable angina or new onset angina or myocardial infarction within the past 6 months
- •Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy
- •Uncontrolled hypertension, defined as systolic blood pressure > 150mm Hg or diastolic pressure > 90mm Hg, despite optical medical management
- •Known human immunodeficiency virus (HIV) infection or chronic Hepatitis B or C
- •Active clinically serious infection > Common Terminology Criteria for Adverse Events (CTCAE) Grade 2
- •Thrombolic or embolic events such as cerebrovascular accident including transient ischemic attack within the past 6 months
- •Pulmonary hemorrhage/bleeding event >/= CTCAE Grade 2 within 4 weeks of first dose of study drug
- •Any other hemorrhage/bleeding event >/= CTCAE Grade 3 within 4 weeks of first dose of study drug
- •Serious non-healing wound, ulcer, or bone fracture
- •Evidence or history of bleeding diathesis or coagulopathy
- •Major surgery, open biopsy or significant traumatic injury within 4 weeks of first study drug
- •Use of St. John's Wort or rifampin
- •Known or suspected allergy to sorafenib or any agent given in the course of the trial
- •Any condition that impairs patient's ability to swallow whole pills
- •Any malabsorption problem
研究组 & 干预措施
sorafenib
干预措施: sorafenib (Drug)
结局指标
主要结局
Toleration of dose escalation (dose-limiting toxicities)
时间窗: One year
次要结局
- Safety of sorafenib in dose-escalation (adverse events and serious adverse events)(One year)