Transcranial Alternating Current Stimulation (tACS) Enhances Neurological Function Recovery Among Post-stroke Patients
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 312
- 试验地点
- 1
- 主要终点
- NIH Stroke Scale (NIHSS) score
研究概览
简要总结
To investigate the efficacy of using transcranial alternating current stimulation (tACS) to enhance the regaining of neurological function among post-stroke patients.
详细描述
Sixty post-stroke patients were randomly assigned to receive 15 sessions of the usual rehabilitation programme with or without tACS. The NIH Stroke Scale (NIHSS) and the mean blood flow velocity (MFV) and Gosling pulsatility index (PI) captured for the middle, anterior, and posterior cerebral artery were the outcome measures.
Fifteen 30-minute sessions of tACS appear to be effective for enhancing post-stroke patients' neurological function. The haemodynamic measures taken indicated that the regaining of function among the patients was largely attributed to a lowering of the vascular autoregulatory activity together with an increase in blood flow velocity at the middle cerebral artery. Future studies should explore the underlying mechanisms mediating the positive effects brought about by tACS in post-stroke rehabilitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosed as first onset intracerebral haemorrhage or infarction (according to ICD-10 I61.0-I61.6 or I63.3-I63.6, with or without I69, i.e.: sequelae of cerebrovascular disease)
- •between 15 and 60 days after the onset
- •right handedness
- •no previous neurological or psychiatric disorders
- •positive transtemporal windows for bilateral middle, anterior, and posterior cerebral arteries insonation (according to the standards set by the Transcranial Doppler Ultrasonographic Device (TCD))
- •NIH Stroke Scale (NIHSS) scores between 14 and 24
- •not receiving rehabilitation before admission
排除标准
- •medical comorbidity preventing the patient undergoing the intervention
- •preceding epileptic fits
- •having metallic implants in the brain or a pacemaker
- •history of surgery to the brain
结局指标
主要结局
NIH Stroke Scale (NIHSS) score
时间窗: 3 weeks
次要结局
- the mean blood flow velocity (MFV)(30 minutes)
- Gosling pulsatility index (PI)(30 minutes)