NCT03184714Unknown不适用
The Effectiveness of Noninvasive Positive Pressure Ventilation Treatment in Overlap Syndrome
Chinese Academy of Medical Sciences, Fuwai Hospital1 个研究点 分布在 1 个国家目标入组 292 人开始时间: 2017年6月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 292
- 试验地点
- 1
- 主要终点
- COPD acute exacerbations
研究概览
简要总结
Chronic obstructive pulmonary diseases (COPD) coexisting with obstructive sleep apnea is called overlap syndrome (OS). Patients with OS seem to have worse prognosis than patients with only one disorder. Noninvasive positive pressure ventilation is an efficient treatment in obstructive sleep apnea, but the effectiveness in improving outcomes of OS patients is still not fully investigated. The aim of this non-randomized concurrent control trial is to evaluate noninvasive positive pressure ventilation's effectiveness in OS patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with COPD and sleep apnea dyspnea syndrome
排除标准
- •patients with non-stable hemodynamics;
- •patients with limited life expectancy;
- •patients with other severe respiratory diseases;
- •patients with motor neuron diseases;
- •patients with contraindications for NIPPV
结局指标
主要结局
COPD acute exacerbations
时间窗: 3 years
total times of COPD acute exacerbations
次要结局
- modified British medical research council (mMRC) score(3 years)
- all-cause mortality(3 years)
- COPD assessment test (CAT) score(3 years)
研究者
Jianguo He
Chief of Pulmonary Vascular Disease Center
Chinese Academy of Medical Sciences, Fuwai Hospital
研究点 (1)
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