cTBS/fMRI Study of Hierarchical Control in the PFC
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 4
- 主要终点
- PFC-PPC Effective Connectivity
研究概览
简要总结
The objective of this study is to examine the effect of transcranial magnetic stimulation (TMS) on the prefrontal cortex and posterior parietal cortex.
详细描述
The Comprehensive Control Task (CCT) was designed to examine hierarchical control in a single, well-controlled factorial task. On each trial, participants view a letter surrounded by a colored shape at a particular screen location. Color cues the relevant feature, letter or location, for a block of trials. The first trial of a block requires a decision of whether the stimulus is the first position of a circular sequence (sequence start). Subsequent trials require a decision of whether the viewed stimulus follows the previous stimulus in a circular sequence (sequence 1-back). The letter sequence (C-O-M-I-C) and spatial sequence (Top Left-Top Right-Bottom Left-Bottom Right-Top Left) are difficulty-matched.
Shape cues the task to perform. Squares indicate the standard baseline task, and each block begins and ends with baseline trials. Different shapes indicate sub-tasks. In Switching blocks, shape-switches (e.g. from square to circle or circle to square) cue the sequence start task. Shape-repeats cue the sequence 1-back task. In Planning blocks, triangle shapes indicate that the stimulus can be ignored (automatic "no" response). All the while, the last square-shaped stimulus must be retained as a reference for the next square-shaped stimulus. Finally, in Dual blocks, diamond shapes indicate switching (sequence start) and also planning. The reversion back to square shapes requires sequence matching to the distal, previous square.
The design is factorial with stimulus-domain x contextual control x temporal control orthogonally manipulated. Full details of the CCT have been previous described in Nee & D'Esposito, 2016; 2017.
The focus in this study will be comparison of FPl-TMS, MFG-TMS, and S1-TMS in an interleaved fMRI-TMS-fMRI design. The logic is to test the apical status of the FPl/MFG through the extent to which TMS impacts other PFC areas and behavior.
Each experiment will begin with 1 session of the CCT with fMRI to localize PFC targets. Each participant will then perform 3 counter-balanced sessions wherein a different site will be targeted by TMS followed immediately by fMRI on the CCT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 18 and 30
- •Right-handed
- •Native English speaker or fluent by the age of 6
排除标准
- •History of psychiatric disorders
- •History of neurological disorders
- •Receiving medications for psychiatric or neurological disorders
- •Familial history of epilepsy
- •Taking any drugs or medications that are pro-epileptic
- •Metal anywhere in the head excluding the mouth
- •Women who are pregnant
结局指标
主要结局
PFC-PPC Effective Connectivity
时间窗: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
effective connectivity among areas of the prefrontal and posterior parietal cortex in the blood oxygenation level dependent (BOLD) signal assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units, but effective connectivity is a rate measure, so is expressed in Hertz\]
PFC-PPC Activation
时间窗: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
blood oxygenation level dependent (BOLD) signal in areas of the prefrontal and posterior parietal cortex assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units\]
次要结局
- Contextual Control Performance (Reaction Time)(baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS))
- Temporal Control x Contextual Control Performance (Reaction Time)(baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS))
- Temporal Control Performance (Error Rate)(baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS))
- Contextual Control Performance (Error Rate)(baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS))
- Temporal x Contextual Control Performance (Error Rate)(baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS))
- Temporal Control Performance (Reaction Time)(baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS))
研究者
Derek Nee
Assistant Professor
Florida State University