The effects of resveratrol on serum apolipoprotein A-I concentrations in men and women with low HDL-cholesterol concentrations. - Resveratrol and serum apo A-I

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•aged between 45 and 70 years
•HDL-C <1.21 mmol/L (men)
•HDL-C <1.53 mmol/L (women)
•serum total cholesterol <8.0 mmol/L
•plasma glucose <7.0 mmol/L
•BMI between 25 - 35 kg/m2
•non-smoking
•willingness to abstain from resveratrol rich products from two weeks prior to the study and the duration of the study:
•o wine (red and white)
•o all berries
•o peanut butter
•o soy (products)
•o pomegranate

•unstable body weight (weight gain or loss >3 kg in the past 3 months)
•indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
•use of medication or a medically-prescribed diet known to affect serum lipid or glucose metabolism. Oral anti-contraceptives and paracetamol are allowed.
•Active cardiovascular disease (for instance congestive heart failure) or recent (<6 months) event, such as acute myocardial infarction or cerebro-vascular accident
•not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in plant stanol or sterol esters 3 weeks before the start of the study
•men: consumption of >21 glasses of alcohol-containing drinks per week
•women: consumption of >14 glasses of alcohol-containing drinks per week
•abuse of drugs
•pregnant or breastfeeding women
•participation in another biomedical study within 1 month prior to the screening visit
•having donated blood (as blood donor) within 1 month prior to the screening visit or planning to do so during the study
•impossible or difficult to puncture as evidenced during the screening visits

发起方

Medisch Universitair Ziekenhuis Maastricht