NCT06150547已完成不适用
Pilot Imaging Study for CNS Metabolism
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Number of subjects in whom glutamate metabolite is detected and measurable.
研究概览
简要总结
This study is being done to determine if CEST magnetic resonance imaging (MRI) and FDG PET are feasible techniques to detect metabolic differences between tumor and brain in patients with a brain tumor.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Radiographic evidence or histopathologic confirmation of CNS malignancy, with or without prior resection.
- •Provide written informed consent for the current study.
- •Willing to undergo at least one MRI (and possibly more at PI discretion) with proton and/or phosphorus magnetic resonance spectroscopy analysis.
排除标准
- •Vulnerable populations: pregnant or nursing women (Arm B exempt), prisoners, mentally handicapped.
- •Cardiac pacemaker or artificial heart valve
- •Metal plate, pin, or other metallic implant
- •Intrauterine device, such as Copper-7 IUD
- •Insulin or other drug pump
- •Non-titanium aneurysm clips
- •Previous gunshot wound
- •Cochlear implant or other hearing device
- •Employment history as a metalworker (had metal in eye)
- •Permanent (tattoo) eye-liner
- •For FDG-PET specifically: Fasting blood sugar level greater than 200mg/dl
结局指标
主要结局
Number of subjects in whom glutamate metabolite is detected and measurable.
时间窗: Baseline
Number of subjects in whom glutamate metabolite is detected and measurable via CEST MRI in tumor, brain, and/or the ventricular space.
Number of subjects in whom n-acetylaspartate (NAA) metabolite is detected and measurable.
时间窗: Baseline
Number of subjects in whom n-acetylaspartate (NAA) metabolite is detected and measurable via CEST MRI in tumor, brain, and/or the ventricular space.
次要结局
- Time required to perform the CEST MRI study and measure metabolites of interest(Duration of CEST MRI scan, approximately one to two hours.)
研究者
研究点 (1)
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