Study of Medication for Nonallergic Rhinitis (NAR) Based on Cluster Analysis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Relief of bothersome symptoms
研究概览
简要总结
Chronic rhinitis (CR) is one of the most common nasal mucosal diseases in the world. In China, about 140 million people suffer from this disease. Chronic rhinitis can lead to severe economic and social burden, as well as the potential risk of developing other chronic diseases such as asthma and chronic sinusitis. Therefore, it is of great significance to explore the classification and treatment strategies of chronic rhinitis in order to improve the health level of Chinese people.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Not younger than 18 years old
- •Diagnosed as idiopathic rhinitis
- •Signed and volunteered for the study
排除标准
- •Comorbid airway diseases including (but not limited to) upper airway infection, chronic rhinosinusitis, nasal polyps
- •Allergic to the medicines about to study
- •Having used oral glucocorticoids or antihistamine agents within 30 days of the enrollment
研究组 & 干预措施
A: Placebo group
Treated by 0.9% Natural saline (NS) nasal spray: 2 sprays each side daily in the morning
干预措施: 0.9% natural saline (Drug)
B: Budesonide Nasal Spray (Rhinocort)
Treated by Budesonide Nasal Spray (Rhinocort, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) nasal spray: 2 sprays each side daily in the morning
干预措施: Budesonide Nasal Spray (Rhinocort, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) (Drug)
C: Levocabastine Nasal Spray (Livostine)
Treated by Levocabastine(Livostinet, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) Nasal Spray: 2 sprays each side daily in the morning
干预措施: Levocabastine Nasal Spray (Livostine, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) (Drug)
D: Combined Treatment
Treated by Budesonide Nasal Spray (Rhinocort, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) nasal spray: 2 sprays each side daily in the morning and Levocabastine(Livostinet, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) Nasal Spray: 2 sprays each side daily in the morning
干预措施: Budesonide Nasal Spray (Rhinocort, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) (Drug)
D: Combined Treatment
Treated by Budesonide Nasal Spray (Rhinocort, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) nasal spray: 2 sprays each side daily in the morning and Levocabastine(Livostinet, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) Nasal Spray: 2 sprays each side daily in the morning
干预措施: Levocabastine Nasal Spray (Livostine, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.) (Drug)
结局指标
主要结局
Relief of bothersome symptoms
时间窗: 2 weeks
Determined by change of visual analog scale for symptoms
次要结局
未报告次要终点