NCT06866652招募中不适用
Evaluating Dyspnea in Autoimmune Myasthenia Gravis "Why am I Short of Breath?"
Institut de Myologie, France1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2026年4月8日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Dyspnea questionnaires
研究概览
简要总结
Individuals with MG (IwMG) experience shortness of breath that may be activity-related, occur at rest and even happen during sleep. Dyspnea is a complex, multidimensional and multifactorial symptom involving sensory perception, cognition and emotion. Identifying the cause(s) of dyspnea in MG may assist in finding therapeutic strategies, reducing discomfort, improving QoL and potentially limiting respiratory deterioration and incidence of MG crisis.
详细描述
MYaResp is a prospective observational, cross-sectional study to evaluate dyspnea in adults with autoimmune myasthenia gravis.
Study aims include to:
- Describe the characteristics of dyspnea in IwMG
- Understand contributing factors and factors associated with dyspnea in IwMG including the relationship between patient-reported dyspnea, disease severity and functional limitations.
- Determine the most effective tests to identify the causes and contributing factors of dyspnea
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed diagnosis of autoimmune MG
- •Shortness of breath in daily life: score 1 or 2 on the respiration item on the MG- activities of daily living score
- •Signed consent form
- •Affiliated to or beneficiary of a social security scheme
排除标准
- •Known Pregnancy
- •Known respiratory disorder (other than MG)
- •Recent (within past 4 weeks) respiratory infection
- •Current MG crisis or exacerbation (necessitating increase in MG medication &/or hospital admission)
- •No dyspnea - score 0 or 3 on the respiration item on the MG- activities of daily living score
- •Severe cognitive impairment/guardianship
结局指标
主要结局
Dyspnea questionnaires
时间窗: baseline
Dyspnea-12
次要结局
- cardiopulmonary exercise test(baseline)
- Polysomnography(baseline)
- Functional measures(baseline)
- Quality of life questionnaires(baseline)
- Anxiety and depression(baseline)
研究者
研究点 (1)
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