TRAIN-BW: Backward Walking Training in Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Sway during quiet stance
研究概览
简要总结
Individuals with multiple sclerosis (MS) experience in impairments in mobility and cognition that increase the risk for accidental falls. More than 50% of individuals with MS experience injurious falls within a 6-month period. Current interventions to improve fall risk have focused on forward walking (FW) and balance training, resulting in small declines in the relative risk for falls with a large degree of variability. Interestingly, motor differences between MS and healthy controls are more pronounced in backward walking (BW), yet no studies have investigated BW training as an intervention to reduce fall risk in persons with MS. This study will investigate the feasibility, acceptability and impact of BW training compared to forward walking training on motor function and fall risk in persons with MS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of MS
- •PDDS <6, indicating ability to ambulate with or without an assistive device >/= 50% of the time
- •Self-reported walking dysfunction as evidenced by a score of >/= 30 on MSWS-12 OR reports of 2 or more falls in the prior 6 months, indicating a frequent faller.
排除标准
- •MS relapse within the past 30 days
- •comorbid neurological disorder
- •acute orthopedic disorder/injury
- •unable to follow study-related commands
研究组 & 干预措施
TRAIN-FW
1x/week for 8 weeks + home exercise program
干预措施: Forward Walking Training (Behavioral)
TRAIN-BW
1x/week for 8 weeks + home exercise program
干预措施: Backward Walking Training (Behavioral)
结局指标
主要结局
Sway during quiet stance
时间窗: Change in sway at 8 weeks
Measured with APDM Sensors
Stepping latency on push-and-release test
时间窗: Change in stepping latency at 8 weeks
Measured with APDM Sensors
次要结局
- Number of Active Minutes(Change in Physical Activity measures at 8 weeks)
- Number of Falls(6 months)
- Forward and Backward Velocity and Double Support Time(Change in velocity and double support time at 8 weeks)
- Patient Global Impression of Change(8 weeks)
- Client Satisfaction Questionnaire (CSQ-8)(8 weeks)
- ABC Scale(Change in balance confidence at 8 weeks)
研究者
Nora Fritz
Associate Professor
Wayne State University