Muscular Force Generation in Microgravity (ForceGeneration)
试验速览
- 阶段
- 不适用
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- maximum voluntary contraction (MVC)
研究概览
简要总结
The aim of this study is to evaluate the applicability of high-load resistance training as a countermeasure for long term space flights, the current project has two scientific goals.
The main objective is to perform a deeper examination of muscle function and MVC in weightlessness (parabolic flight).
The secondary objective is to gather further insight into the underlying mechanisms and structures based on investigations targeting the neuromuscular and musculotendinous systems and their interaction.
详细描述
The findings from water immersion indicated that some motor tasks, such as plantarflexion (25), but not others, such as the leg-press (7), appear to be affected. Thus, it would be relevant to test a number of motor tasks and body regions. On the other hand, parabolic flight requires that methodologies can be performed in a quick efficient fashion. Hence, we propose examining ankle plantarflexion, leg-press and grip-force.
The primary hypothesis is that plantarflexion MVC will be reduced in the microgravity phase of parabolic flight.
As secondary parameters will be assessed parameters of muscle function that can be easily implemented in parabolic flight, such as electromyography and ultrasound measurements of the musculotendinous unit. To assess the muscular system more deeply, for plantarflexion superimposed twitches will be performed (16) during MVC and at rest. An additional experimental condition placing foam (unstable surface; standard size) under the foot during plantarflexion will be included. This approach increases the challenge for the neuromuscular control system and, under such conditions, MVC is reduced (29).
These secondary investigations, which do not prohibitively complicate the practical implementation of the project, will help to understand what is happening in the musculature should we indeed find impediments of muscle force generation in microgravity.
The aim of this study is to evaluate the applicability of high-load resistance training as a countermeasure for long term space flights, the current project has two scientific goals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers (men or women)
- •Aged from 21 to 65
- •Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC)
- •Who accepted to take part in the study
- •Who have given their written stated consent
- •Who have their right leg as their preferred leg
- •Who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There will be no additional test performed for subject selection.
- •Subjects will be staff member of the team or of other teams participating in the parabolic flight campaign
排除标准
- •Person who took part in a previous biomedical research protocol, of which exclusion period is not terminated
- •Person with orthopaedic disorders in the upper or lower limbs
- •Person with neurological disorders
- •Pregnant women
研究组 & 干预措施
high-load resistance training for long term space flights
Short duration electrical will be delivered and the resulting EMG will be recorded. Intensity of electrical stimulation will be progressively increased until we observed a maximal EMG response.
Finally an ultrasound probe (similar to that used for prenatal diagnostic imaging) will be fixed behind your calf in order to visualize muscle.
干预措施: examination of muscle function and MVC in weightlessness (Other)
结局指标
主要结局
maximum voluntary contraction (MVC)
时间窗: baseline
tested during three different tasks: (1) leg press, (2) plantarflexion and (3) grip strength.
次要结局
- parameters of muscle function, Electromyographic activity(baseline)
- parameters of muscle function, Ultrasound measure: fascicle length(baseline)
- parameters of muscle function, Ultrasound measure: pennation angle of the gastrocnemius medialis muscle(baseline)
- parameters of muscle function, Superimposed twitch torque (M-waves at rest and V-waves in MVC conditions)(baseline)
- parameters of muscle function, Rate of force development(baseline)
- parameters of muscle function, Maximum voluntary activation capacity (%VA): %VA = (1-[torque superimposed twitch/torque resting twitch])*100%.(baseline)