A Comparative Trial of TMS Approaches to Treating Depression
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Montgomery-Åsberg Depression Rating Scale(MADRS)
研究概览
简要总结
Trancranial Magnetic Stimulation (TMS) is a non-drug and non-invasive treatment for depression and has been investigated for the treatment of psychiatric illness for over 15 years. There is now established evidence indicating TMS is an effective treatment for depression. However, the effectiveness of TMS varies between people, thus requiring further research to investigate its optimal application. Investigators want to compare the effectiveness of different forms of TMS, given with differing stimulation settings to the right or left side of the brain that has been associated with depression. This could potentially help clinicians in the future to improve the prescription of TMS as a treatment for depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years.
- •DSM-IV diagnosis of current Major Depressive Episode.
- •MADRS score of 20 or more.
- •Able to give informed consent.
排除标准
- •DSM-IV psychotic disorder.
- •Drug or alcohol abuse or dependence (preceding 3 months).
- •Inadequate response to ECT (current episode of depression).
- •Rapid clinical response required, e.g. high suicide risk.
- •Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy.
- •Metal in the cranium, skull defects, pacemaker, cochlear implant, medication pump or other electronic device.
结局指标
主要结局
Montgomery-Åsberg Depression Rating Scale(MADRS)
时间窗: Participants will be assessed for changes for duration of trial, an expected average of 6 weeks.
次要结局
未报告次要终点
研究者
Colleen Loo
Professor Colleen Loo, Black Dog Institute, The Prince of Wales Hospital
The University of New South Wales