ISRCTN61552714已完成不适用
Randomised, placebo controlled trial of itraconazole in the treatment of fungal sensitised patients with severe asthma and without allergic bronchopulmonary aspergillosis (ABPA)
South Manchester University Hospitals NHS Trust (UK)0 个研究点目标入组 100 人开始时间: 2005年11月21日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Asthma requiring: high dose inhaled steroids or continuous steroids or at least 4 courses oral/intravenous (IV) steroids over previous 12 months or at least 6 courses oral/IV steroids over the previous 24 months
排除标准
- •1. ABPA (IgE >1000, precipitins positive)
- •2. Recurrent bacterial chest infections
- •3. Allergy to Azoles
- •4. Pregnancy
- •5. Current treatment with drugs that interact with itraconazole and which cannot be stopped
- •6. Significant cardiac disease
- •7. Significant immunosuppression other than corticosteroids
- •8. Abnormal liver function tests
研究者
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