aparoscopic Appendicectomy versus Antibiotics for Imaging Confirmed Acute Uncomplicated Appendicitis: A Multisite Randomised Controlled Trial

niversity of Queensland0 个研究点目标入组 300 人开始时间: 2020年5月1日最近更新: 2020年5月11日

适应症

试验速览

暂无简介。

•Uncomplicated acute appendicitis as deemed by reporting radiologist at time of admission
•- Clinical diagnosis of appendicitis as per treating physician
•- Age 18 to 50, both males and females
•- Able to speak English and consent to follow up

•- Age < 18 or > 50
•- Severe sepsis / septic shock / medically unstable as per treating physician
•- Severe peritonitis (as per treating physician)
•- Abdominal surgery within last month
•- Received antibiotics within last week
•- Allergy to all study antibiotics
•Co-morbidities
•- Pregnancy
•- Complex diabetes: requiring any medication (e.g. metformin, insulin), ketoacidosis or coma
•- Immunodeficiency
•- Ischaemic heart disease, Congestive heart failure, Congenital heart disease
•- Cardiac surgery or coronary stents
•- Takin aspirin, antiplatelet, anticoagulant medications
•- History of bleeding disorders
•- History of chronic liver disease, cirrhosis, liver failure
•- Chronic renal insufficiency (eGFR < 40), haemodialysis, peritoneal dialysis, plasmapheresis
•- Concurrent severe illness requiring hospitalization
•- Other infection requiring antibiotic treatment
•- Intravenous drug use (ever)
•- Cognitive impairment, intellectual disability, severe mental illness
•- Previous colonic or small bowel surgery
•- Any active malignancy apart from non-metastatic skin cancer
•- Inability/unwilling to return for follow up
•- Inability to provided written informed consent
•- Non-English speaker
•Radiological Exclusion Criteria
•- CT / USS evidence of complicated appendicitis (phlegmon, abscess, perforation)
•- Presence of faecolith
•- Any radiological suspicion for alternative diagnosis or malignancy

发起方

niversity of Queensland