The Effect of Smoking and Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Cyclophilin A and EMMPRIN Levels
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 主要终点
- Change in gingival crevicular fluid EMMPRIN total amounts
研究概览
简要总结
This study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid CyPA and EMMPRIN levels in patients with periodontitis. Twenty-eight patients with periodontitis (14 non-smoker and 14 smoker) and 30 control subjects (15 non-smoker and 15 smoker) were included into the study. Non-surgical periodontal treatment was applied to all periodontitis patients. Periodontal parameters and GCF CyPA and EMMPRIN levels were evaluated during 3 months following non-surgical periodontal treatment. GCF CyPA and EMMPRIN levels were analyzed by ELISA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 29 Years 至 61 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •generalized periodontitis with stage III-IV & Grade B
- •no systemic and periodontal diseases
- •smokers (minimum 10 cigarettes per day for at least ten years)
- •non-smokers (never smoked)
排除标准
- •Systemic diseases
- •Infectious diseases
- •Pregnancy or lactating
- •Having periodontal treatment during the last 6 months
- •Having antibiotic treatment within the past 3 months
- •Former smokers
研究组 & 干预措施
smoker
干预措施: non-surgical periodontal treatment (Procedure)
non-smoker
干预措施: non-surgical periodontal treatment (Procedure)
结局指标
主要结局
Change in gingival crevicular fluid EMMPRIN total amounts
时间窗: Baseline, 1 week, 1., 3. months
GCF EMMPRIN levels were analyzed by ELISA
Change in gingival crevicular fluid CypA total amounts
时间窗: Baseline, 1 week, 1., 3. months
GCF CyPA levels were analyzed by ELISA
次要结局
- Change in bleeding on probing(Baseline, 1., 3. months)
- Change in probing depth(Baseline, 1., 3. months)