Oculomotor Deficits in Parkinson's Disease: Enhancing Eye Movement Performance and Dynamic Visual Acuity With Oculomotor Training Using a Pilot Randomized Clinical Trial Design
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Smooth Vergence eye movements
研究概览
简要总结
Parkinson's disease (PD) is a common neurodegenerative disorder which is characterized by both motor and non-motor symptoms and usually affects people aged 50 years or above. Many studies showed eye movement deficits and visual changes in patients with PD.
Previous studies have also indicated that clinical eye movement training could enhance the functional performance of patients with various eye movement problems resulting from ocular and neurodegenerative diseases.
In this study, we will investigate the effectiveness of eye movement training on dynamic vision and functional performance in PD patients with oculomotor deficits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's Disease diagnosed by a neurologist or geriatrician with the range of Stage
- •1 to 4 (Hoehn and Yahr Classification)
- •Able to speak and comprehend Cantonese dialect
- •Able to travel independently
排除标准
- •Any congenital eye problem (e.g. congenital strabismus or amblyopia in either eye) or any manifest eye diseases (e.g. macular degeneration, glaucoma, etc)
- •Severe medical problems (e.g. stroke)
- •Cognitive impairment (e.g. dementia)
- •Presence of any psychiatric or neurological diseases (apart from Parkinson's disease) or receiving of any psychoactive pharmacological treatment
- •Receiving any medication that is known to affect eye movement and cognitive function
- •Previous formal vision rehabilitation or oculomotor intervention
研究组 & 干预措施
Control Group
Receive 10 sessions of 45-minute (3 sessions per week) in-office leisure activities e.g. simple non-action computer games or board games (e.g. card and chess games) and 10-20 minutes of video watching at home
干预措施: Control Group (Other)
Intervention Group
Receive 10 sessions of 45-minute office training (3 sessions per week) and 10-20 minute home training (3 sessions per week) of eye movement training
干预措施: Oculomotor Training Group (Other)
结局指标
主要结局
Smooth Vergence eye movements
时间窗: Change from baseline at week 4 and change from baseline at week 12
Smooth vergence eye movement is measured using a head-mounted eye tracking while fixating at an approaching target moving at different speeds
次要结局
- Oculomotor characteristics(Change from baseline at week 4 and change from baseline at week 12)
- Sentence reading performance(Change from baseline at week 4 and change from baseline at week 12)
- Passage reading performance(Change from baseline at week 4 and change from baseline at week 12)
研究者
Allen MY Cheong
Associate Professor
The Hong Kong Polytechnic University