NCT00703742已完成不适用
A Neuroimaging and Epigenetic Investigation of Antidepressants in Depression
Kunming Medical University1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2008年6月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- change of fMRI after medication
研究概览
简要总结
The purpose of this study is:
- to find out the structural or functional effects of selective serotonin reuptake inhibitors (SSRI) in major depressive disorder (MDD);
- find special abnormalities in depression secondary to other disease, e.g., autoimmune disease like systemic lupus erythematosus (SLE).
- find the relationship between the efficacy of antidepressant and the change of neuroimaging in MDD
- to find possible predispose to MDD
- to explore the DNA methylation status in depression;
详细描述
- to explore the pathology of depression
- to identify the difference between MDD and depression secondary to other disease ,especially autoimmune disease
- to explore the effect of gene-environment interaction on the epigenetic regulation of the depression
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •DSM-IV Major Depression or Dysthymia
- •Age 18-65
- •Physically healthy
- •Drug-free
排除标准
- •Body metal (e.g., wire stitches, screws in bones, stainless steel hips)
- •History of Psychosis or Epilepsy
- •Current (past six months) Substance Use Disorder (illicit drugs and/or alcohol)
- •Bipolar I
- •Need for wash-out from effective treatment in order to participate
- •High suicide risk
- •Currently taking (within 2 weeks; 4 weeks for Fluoxetine) antidepressants
研究组 & 干预措施
A,1
Experimental
A: Escitalopram, 20 mg/day,8weeks
干预措施: Escitalopram (Drug)
结局指标
主要结局
change of fMRI after medication
时间窗: baseline, 4 weeks, 8 weeks
次要结局
未报告次要终点
研究者
Yuqi Cheng
Vise director, psychiatry department, Kunming Medical University
Kunming Medical University
研究点 (1)
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