Application of Fecal DNA Methylation and Fecal Helicobacter Pylori Gastric Cancer Susceptibility Genes in Clinical Diagnosis, Treatment, and Relapse and Metastasis of Gastric Cancer
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Positive predictive value of early diagnosis of gastric cancer
研究概览
简要总结
Based on the detection technology of methylation sites in feces, combined or not combined with Helicobacter pylori gastric cancer susceptibility gene detection, an early diagnosis and detection system for gastric cancer is established, and the clinical diagnostic value of the detection system is evaluated. In addition, the study observed the association between different loci and post-treatment recurrence, metastasis, or long-term survival rate through long-term follow-up of gastric cancer patients; Follow up with individuals with benign diseases such as gastritis and healthy individuals, compare cases of gastric cancer, and compare their sample data during follow-up with controls who did not have the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 years old, male or female not limited.
- •Within 90 days, the gastroscopy and/or pathological results confirm the absence of gastric cancer.
- •Patients must be able to fully understand the informed consent form and be able to personally sign it.
排除标准
- •Severe heart, liver, kidney dysfunction, or mental illness.
- •History of malignant tumors in the upper gastrointestinal tract.
- •Pregnant women.
- •Those with unclear pathology.
- •Those with unsatisfactory sample retention (such as insufficient sample size).
结局指标
主要结局
Positive predictive value of early diagnosis of gastric cancer
时间窗: baseline
次要结局
未报告次要终点
研究者
Dazhi Xu
Director of the gastric surgery department
Fudan University