Protective Ventilation Strategy During One-lung Ventilation: Effect on Postoperative Pulmonary Complications
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- postoperative pulmonary complications
研究概览
简要总结
The purpose of this study is to find a proper ventilation strategy for one-lung ventilation to prevent postoperative pulmonary complications
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing elective thoracic surgery
- •ASA I, II, III
- •scheduled > 2 hours of surgery
排除标准
- •denied patients
- •age under 18 years
- •FEV1/FVC or FEV1<70% in preoperative pulmonary function test
研究组 & 干预措施
conventional tidal group
provide tidal volume of 6ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation
干预措施: ventilator setting during one-lung ventilation (Other)
low tidal group
provide tidal volume of 4ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation
干预措施: ventilator setting during one-lung ventilation (Other)
high tidal group
provide tidal volume of 8ml/kg (predicted body weight) with positive end expiratory pressure of 5cmH2O during one-lung ventilation
干预措施: ventilator setting during one-lung ventilation (Other)
结局指标
主要结局
postoperative pulmonary complications
时间窗: immediately after operation
PaO2/FiO2 and/or newly appeared atelectasis, lung infiltration
次要结局
未报告次要终点
研究者
Jae-Hyon Bahk, MD, PhD
Professor
Seoul National University Hospital