The Impact of Meditation Practice on Attention and Emotion Regulation :Studies on Neural Correlation in Brain Imagery and Biomarkers of Stress and Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 169
- 试验地点
- 2
- 主要终点
- Functional MRI scan
研究概览
简要总结
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age : 25-70
- •Being affiliated to a social security system.
- •Motivated to participate in this study.
排除标准
- •Medication acting on the central nervous system
- •Opioids, Antidepressive Agents.
- •Actual or previous neurological or psychiatric illnesses
- •Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
- •Not having a personal or family history of epilepsy
- •Alcohol or drugs consumption 2 days before or during the study.
研究组 & 干预措施
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Magneto-encephalography (MEG) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Electro-encephalography (EEG) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Functional Magnetic Resonance Imaging (fMRI) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
1. Participants without meditation experience
Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Meditation (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Magneto-encephalography (MEG) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Electro-encephalography (EEG) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Functional Magnetic Resonance Imaging (fMRI) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
2. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.
干预措施: Meditation (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Magneto-encephalography (MEG) (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Electro-encephalography (EEG) (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Functional Magnetic Resonance Imaging (fMRI) (Other)
3. Participants without meditation experience
Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Magneto-encephalography (MEG) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Electro-encephalography (EEG) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Functional Magnetic Resonance Imaging (fMRI) (Other)
4. Participant with a significant meditation experience
Experts : > 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).
干预措施: Anatomical Magnetic Resonance Imaging (aMRI) (Other)
结局指标
主要结局
Functional MRI scan
时间窗: Day1
Brain activation: Haemodynamic response - BOLD signal.
EEG
时间窗: Day 1
Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT\^2/Hz
Anatomical MRI scan
时间窗: Day 1
Brain structure
次要结局
- Electrogastrogram(Day 1)
- Behavioral measure : Accuracy of the performed task actions(Day 1)
- Psychophysics: Pain threshold(Day 1)
- Psychophysiology : Respiration(Day 1)
- Subjective experience of the participant(Day 1)
- Studies biomarkers of inflammation(Day 1)
- Behavioral measure : Speed of the performed task actions(Day 1)
- Psychophysiology : Heart(Day 1)
- Psychophysiology : Heart rate variability(Day 1)
- Psychophysiology : Muscles(Day 1)
- Psychophysiology : Eyes(Day 1)
- Psychophysiology : Pupillar response(Day 1)