Autologous Perichondrium Transplantation for Replacement of Stem Cells and Their Niche in the Treatment of Necrotizing Scleritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Success Rate of Repair of Scleral Defects
研究概览
简要总结
Necrotizing scleritis with severe ischemia is refractory to conventional treatment because of avascular necrosis.
The investigators assessed the therapeutic efficacy and safety of autologous perichondrium transplantation in patients with severe ischemic necrotizing scleritis, and analyzed the therapeutic effects.
详细描述
Ischemic necrotizing scleritis patients who showed persistent and progressive scleral melting were included in this study.
Perichondrium tissue was harvested from the patient's ear cartilage and transplanted to reconstruct the scleral defect after the necrotic tissue removal.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •impending perforation or perforation state of sclera;
- •graft melting following previous surgery;
- •bacterial or fungal infection of sclera or graft after previous surgery;
- •discomfort due to protrusion of scleral calcification with ischemic necrosis
- •broad avascular area larger than 10 mm in diameter
排除标准
- •asymptomatic patients
- •smaller scleral defect less than 10 mm in diameter
- •shallow scleral defect
研究组 & 干预措施
Perichondrium
Perichondrium Autografts
干预措施: Perichondrium Autografts (Procedure)
结局指标
主要结局
Success Rate of Repair of Scleral Defects
时间窗: Six months after reconstructive surgery
Success Rate of Repair of Scleral Defects
次要结局
- Post-Operative Complications(Six months after reconstructive surgery)
研究者
Jae Chan Kim
Professor
Chung-Ang University Hosptial, Chung-Ang University College of Medicine