Evaluation of Procalcitonin and C-Reactive Protein as a prognostic marker among Sepsis patients in Oncology ICU

Adult patients  admitted in oncology ICU aged > 18 will be screened for sepsis as SOFA score > 2. The Primary objectiveis to evaluate PCT and CRP as a marker in predicting mortality among sepsis patients in oncology ICU ; our  Secondary objective is to assess the correlation of  PCT and CRP with SOFA score in predicting severity of disease. and to assess the correlation of PCT and CRP with length of ICU stay. PCT, CRP  will be measured on Day 0, 2 and 4. Patients  will be followed up for a mortality, duration of ICU stay and recovery. At 28 th day  patient/ patient’s attender will be called telephonically to assess for mortality or recovery. The discriminant performance of Day 0, 2, and 4 values of CRP and PCT in predicting within 28-day mortality will be assessed using the ROC curve analysis. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) will be calculated.