Assessment of Cancer Related Brain Fog Using the Test of Strategic Learning
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Number of months to recruit
研究概览
简要总结
The Inova research team will ask people who have had an experience of breast cancer and related changes to their cognition to complete some scales that researchers have established describe brain fog (called patient reported outcomes) and compare those results to the TOSL results. This will be done twice to see if changes are detected similarly on both types of measures.
详细描述
Current brain fog research struggles to clearly define and measure brain fog because the changes are more subtle than typically show up on "objective" tests. These subtle changes on the tests, may not appear subtle in everyday life. This disconnect can lead to people managing cancer feeling unheard or unbelieved about their experience with brain fog. However, cognitive research outside of the cancer population has developed and tested tests that are more sensitive to cognitive changes and improvements. The goal of this initial research project is to test a more sensitive test, called the Test of Strategic Learning (TOSL), to see if it is sensitive enough to objectively measure brain fog.
One other problem with previous brain fog research is that it has not included a diverse population. Therefore, what we think we know about brain fog may not be true for everyone with brain fog. The diverse population in the DMV area that Inova serves deserves to have their experiences represented in the research.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years of age or older
- •ECOG performance status ≤ 2
- •Patients diagnosed or with a history of breast cancer within the last 5 years.
- •Life expectancy of at least 3 months
- •Subject reports experiencing brain fog or cognitive impairment that the subject attributes to cancer or cancer therapy
- •Able to sit for one hour and attend and respond to verbal and written instructions.
- •Able to use a computer
排除标准
- •Brain metastases from breast cancer
- •Severe hearing or visual impairment
- •Unable to give informed consent
- •Unable to read and write in English
- •Those diagnosed with history of neurologic injuries or disorders (e.g. seizures, strokes, traumatic brain injury, brain surgery, neurodegenerative disorders) other than those attributable to cancer or cancer therapy.
结局指标
主要结局
Number of months to recruit
时间窗: 4 months
Number of months between opening of recruitment and recruitment date of the 10th subject.
Correlation between the TOSL score and PAOFI score
时间窗: 6 months
Spearman correlation coefficient between the TOSL Lessons score and the PAOFI higher level cognition subscale score.
次要结局
未报告次要终点