A Randomized open-label clinical study on the efficacy of Vishwadi Guggulu with Ksheerbala 101 Avartana Taila Pratimarsha Nasya with special reference to Parkinsons disease and its comparison with the efficacy of Kapikacchu Choorna with Ksheerbala 101 Avartana Taila Pratimarsha Nasya.

Parkinson disease is a progressive neurodegenerative disorder that mainly affects elderly people and causes tremors rigidity slow movements and gait problems. It is the second most common neurodegenerative disease worldwide and its global burden has increased significantly over the past decades with further rise expected in the coming years. In India it represents a major proportion of neurodegenerative disorders. Current treatments such as Levodopa and dopamine agonists provide symptomatic relief but are associated with behavioral and non behavioral side effects.

In Ayurveda Parkinson disease closely resembles Kampavata a disorder related to Vata Dosha. Symptoms described in classical texts include tremors in hands and feet giddiness discomfort disturbed sleep and cognitive decline which greatly affect quality of life. Although Ayurveda offers potential therapies for Vata disorders there is limited modern clinical evidence supporting its role in managing Kampavata. Therefore scientific evaluation is needed.

Vishwadi Guggulu mentioned in classical texts is considered beneficial for managing tremors and is selected for evaluation in this study. Kapikacchu known for its nourishing and Vata balancing properties and as a natural source of L dopa is chosen as a comparative drug. In addition Pratimarsha Nasya using Ksheerabala 101 Avartana Taila is administered in both groups based on the Ayurvedic principle that the nose acts as a gateway to the brain helping to balance Vata in the central nervous system