STUDY OF FACTORS FAVORING THE ONSET OF NOVO ATRIAL FIBRILLATION IN THE IMMEDIATE AFTERMATH OF CORONARY ARTERY BYPASS SURGERY
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Onset or a de novo episode of atrial fibrillation during the 7 days following heart surgery
研究概览
简要总结
Before la surgery:
Transthoracic cardiac echography will be done systematically, to measure among other things the size of the left atrium.
During surgery:
Surgery under extracorporeal circulation: tissue samples will be harvested from the right atrium (one before clamping of the aorta (T0= pre-ischemia sample), immediately before declamping of the aorta (T1= post-ischemia sample).
Surgery without extracorporeal circulation: tissue samples from the right atrium before CABG (T0) and a second sample after CABG (T1).
In parallel with the harvesting of cardiac tissue, blood samples will be taken at different times (H0, H3, H24) to correlate tissue data with systemic data. These will be taken by the anesthetists.
After the surgery:
Holter ECG will be set up for 7 days of continuous recording. Each patient will fill in an observation notebook. The biological samples will be analysed immediately and the biological data obtained will be recorded in the observation notebook.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have provided written informed consent
- •Patients covered by the national health insurance scheme
- •Heart surgery (CABG) with and without extracorporeal circulation
- •Elective or deferred emergency surgery
- •Consecutive patients aged less than 80 years
排除标准
- •Patients less than 18, under guardianship
- •Patients over 18, under guardianship
- •Patients who do not understand the study data
- •Patients undergoing emergency surgery who therefore cannot be given or understand the explanations for the study (patients in shock, intubated patients with mechanical ventilation)
- •History of heart surgery
- •History of AF
- •Treatment with Cordarone.
结局指标
主要结局
Onset or a de novo episode of atrial fibrillation during the 7 days following heart surgery
时间窗: 7 days post-surgery
次要结局
- Markers of ischemia: circulating Troponin I before the surgery and at the end of the procedure(Baseline and at the end of surgery (15 minutes after unclamping when extracorporeal circulation))