Ridge Augmentation Using Autologous Concentrated Growth Factors (CGF) Enriched Bone Graft Matrix (Sticky Bone) Versus Guided Bone Regeneration Using Native Collagen Membrane in Horizontally Deficient Maxilla
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 主要终点
- Horizontal bone gain
研究概览
简要总结
Guided bone regeneration (GBR) using bone graft and barrier membrane is a well-established technique for augmentation of atrophic alveolar ridges. There are many techniques for ridge augmentation involves the use of bone grafting materials, barrier membranes, possibly some tenting/fixation screws the stability of bone graft, space maintenance, angiogenesis, and tension free primary suture are essential for success.
详细描述
Common techniques introduced for horizontal ridge augmentation are Guided Bone Regeneration (GBR), there are many techniques for ridge augmentation involves the use of bone grafting materials, barrier membranes, possibly some tenting/fixation screws. For successful GBR, stability of bone graft, space maintenance, angiogenesis, and tension free primary suture are essential. Space maintenance with particulate bone graft should be provided during healing period. However particulate bone graft is easily migrated when grafted on the large horizontal bone defect. To reconstruct large bony defect or for the 3-dimensional ridge augmentation, bone tack on the collagen membrane or titanium mesh is required to contain particulate bone graft during healing but these procedures are surgically time consuming and technique sensitive.
Sticky bone is biologically solidified bone graft which is entrapped in fibrin network. Sticky bone graft doesn't scatter because particulate bone powders are strongly interconnected each other by fibrin network.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inadequate facial bone obviating prosthodontically planned implant placement in the maxilla
- •Both sexes.
- •No intraoral soft and hard tissue pathology
- •No systemic condition that contraindicate implant placement.
排除标准
- •Significant bone-related illness or pathology.
- •Heavy smokers more than 20 cigarettes per day.
- •Patients with systemic disease that may affect normal healing.
- •Psychiatric problems
- •Disorders to implant are related to history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site
- •Immunodeficiency pathology, bruxism, stress situation (socially or professionally).
研究组 & 干预措施
Ridge augmentation with sticky bone and GBR
Ridge augmentation using Autologous concentrated Growth factors (CGF) enriched bone graft matrix (sticky bone) and guided bone regeneration using native collagen membrane in horizontally deficient maxilla
干预措施: Ridge augmentation with sticky bone and GBR (Device)
结局指标
主要结局
Horizontal bone gain
时间窗: 6 months
The amount of horizontal bone gain will be measured by cone beam computed tomography
次要结局
未报告次要终点
研究者
Sarah AbdAllah Mohamed
Principal investigator
Cairo University
